The Tobacco Products Directive (TPD) is not only one of the last major pieces of EU regulation that will be adopted before next year’s elections to the European Parliament (EP). It is also one of the last opportunities to make a meaningful difference not only in the health and well-being of people living in Europe now but also of that of generations to come. Smoking has devastating consequences; from outright death to chronic diseases such as cancer and respiratory diseases like Chronic Obstructive Pulmonary Disease (COPD), to heart attacks – and always a severe impact in the smoker (active and passive) health and well-being. The next plenary vote of the EP on the revision of the Tobacco Products Directive holds the potential to diminish exponentially the damage caused by smoking and to better protect children living in Europe from taking up this deadly habit in the first place.